Biotrepy Versus Pharmacology

Approaches for transplanting the sensitized patient: biology versus pharmacology.

In 1969, Patel and Terasaki [1] reported that a positive cytotoxic crossmatch between donor lymphocytes and recipient serum was associated with early or immediate graft loss. From this seminal finding it quickly became apparent that the clinically relevant antibodies in a positive lymphocyte crossmatch were those directed against antigens encoded by the human major histocompatibility complex (M...

How does antifungal pharmacology differ for mucormycosis versus aspergillosis?

Over the last decade, advances in diagnostic systems and the introduction of new antifungal agents have significantly improved outcomes in immunocompromised patients who develop invasive aspergillosis. However, mortality rates remain relatively unchanged for less common, but highly aggressive, mold infections such as mucormycosis. Recent genome sequencing of Rhizopus oryzae revealed evidence of...

Anesthetic Pharmacology Preclinical Pharmacology

Daniel I. Sessler, MD† BACKGROUND: In previous studies, we showed that failure to respond to automated responsiveness monitor (ARM) precedes potentially serious sedationrelated adversities associated with loss of responsiveness, and that the ARM was not susceptible to false-positive responses. It remains unknown, however, whether loss and return of response to the ARM occur at similar sedation ...

Pharmacology.

A very able review of the present status of the pharmacology of cannabis, active substances and synthetic derivatives, has been given by S. Loewe. In conjunction with other recognized American investigators, Roger Adams, E. J. Wollner, et al., he has himself made important contributions to this subject. The large number of animals at his disposal, for example, 2600 experiments carried out on 15...

Pharmacology